This is an exciting time to be among AIDS vaccine researchers—even more exciting than I anticipated when I accepted the invitation months ago.We have witnessed a significant moment in the AIDS field with the announcement of the results of the Phase III trial in Thailand of a combination HIV vaccine candidate. As you know, the results presented thus far from the Thai trial are modest. Yet that the results are not conclusive is to miss the point—the point is that they provide much needed hope to the scientific community.