We meet at a moment in time when the AIDS response is at a crossroads. We have achieved some lasting gains against the epidemic: The conspiracy of silence has been broken. Over five million people are on lifesaving treatment. Infection rates are dropping. People living with HIV and engaged and active in ways we have never before seen. Young people have reduced their HIV prevalence 25% in 15 of the highest-burden countries. We expect to virtually eliminate mother-to-child transmission of HIV in just a few years